Human CTSB Protein, Recombinant
產(chǎn)品貨號：PR00450HuP2
$ 詢價
規(guī)格：100ug
產(chǎn)品名稱：Human CTSB Protein, Recombinant
純度：≥95 % as determined by SDS-PAGE
內(nèi)毒素：/
生物活性：/
序列起止：Arg18~Ile339
標(biāo)簽：C-His tag
Uniprot鏈接：P07858
表達(dá)系統(tǒng)：E.coli
種屬：Human
預(yù)測 N 端：Met
預(yù)測分子量：/
緩沖液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
運(yùn)輸方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
穩(wěn)定性 & 儲存條件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
復(fù)溶：Please refer to COA for detailed information
別稱：CTS-B, APPS, CPSB, APP secretase
背景信息：Cathepsin B. Cathepsin B is the first described member of the family of lysosomal cysteine proteases (1). Cathepsin B possesses both endopeptidase and exopeptidase activities, in the latter case acting as a peptidyl-dipeptidase. It is known to process a number of proteins, including pro and active caspases, prorenin and secretory leucoprotease inhibitor (SLPI) (2 - 4). Therefore, Cathepsin B may play a role in activation and inactivation of caspases, activation of renin and inactivation of SLPI, the key steps in apoptosis, angiotensin production, and progression of emphysema, respectively. Because of its increased levels and redistribution of the enzyme in human and animal tumors, Cathepsin B may also have role in invasion and metastasis (5).In addition to lysosome, Cathepsin B can be secreted or associated with plasma membrane, cytoplasm, and nucleus. It is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme (1).
全稱：Cathepsin B (CTSB)
說明書：待上傳